NFL Week 2 Odds, Lines, and Matchup Analysis
Week 1 of the 2026 NFL season delivered plenty of surprises, high-scoring affairs, and standout individual performances. As the league turns its attention to Week 2, the action kicks off Thursday night with a marquee matchup between the Detroit Lions and Buffalo Bills — a game that currently carries the highest posted total of the week.
Several intriguing matchups follow on Sunday, including the Chicago Bears hosting the Minnesota Vikings, the Pittsburgh Steelers visiting the New England Patriots, the Denver Broncos taking on the Jacksonville Jaguars, and the Houston Texans facing the Cincinnati Bengals. The slate wraps up Monday night with the Los Angeles Rams looking to rebound from a disappointing Week 1 when they host the New York Giants on Monday Night Football.
Below is a complete look at the odds for every Week 2 game, sourced from DraftKings and subject to change. All odds reflect the current lines as of publication.
Thursday Night Football
Detroit Lions at Buffalo Bills (-3.5)
- Kickoff: Thursday, 8:15 p.m. ET on Prime Video
- Moneyline: Lions (+154); Bills (-185)
- Total: 53.5 (Opened: 52.5)
- FPI Favorite: Bills by 4.2 with a 64% probability to win outright
Sunday Early Slate (1 p.m. ET)
Minnesota Vikings at Chicago Bears (-5.5)
- TV: Fox
- Line Movement: Opened Bears -3.5
- Moneyline: Vikings (+205); Bears (-250)
- Total: 49.5 (Opened: 45.5)
- FPI Favorite: Bears by 2.6 with a 59% probability to win outright
Cleveland Browns at Tampa Bay Buccaneers (-8.5)
- TV: CBS
- Line Movement: Opened Buccaneers -5.5
- Moneyline: Browns (+295); Buccaneers (-375)
- Total: 40.5 (Opened: 42.5)
- FPI Favorite: Buccaneers by 8.3 with a 78% probability to win outright
Philadelphia Eagles (-7) at Tennessee Titans
- TV: Fox
- Line Movement: Opened Eagles -4.5
- Moneyline: Eagles (-310); Titans (+250)
- Total: 40.5 (Opened: 42.5)
- FPI Favorite: Eagles by 5.5 with a 70% probability to win outright
Carolina Panthers (-1.5) at Atlanta Falcons
- TV: Fox
- Line Movement: Opened Falcons -1.5
- Moneyline: Panthers (-125); Falcons (+110)
- Total: 43.5 (Opened: 43.5)
- FPI Favorite: Falcons by 1.8 with a 57% probability to win outright
Green Bay Packers (-4.5) at New York Jets
- TV: Fox
- Line Movement: Opened Packers -6.5
- Moneyline: Packers (-225); Jets (+185)
- Total: 44.5 (Opened: 42.5)
- FPI Favorite: Packers by 3.2 with a 62% probability to win outright
Pittsburgh Steelers at New England Patriots (-5.5)
- TV: CBS
- Moneyline: Steelers (+195); Patriots (-238)
- Total: 41.5 (Opened: 43.5)
- FPI Favorite: Patriots by 4.2 with a 66% probability to win outright
New Orleans Saints at Baltimore Ravens (-8.5)
- TV: CBS
- Moneyline: Saints (+295); Ravens (-375)
- Total: 47.5 (Opened: 46.5)
- FPI Favorite: Ravens by 7.7 with a 77% probability to win outright
Cincinnati Bengals at Houston Texans (-3)
- TV: CBS
- Moneyline: Bengals (+124); Texans (-148)
- Total: 46.5 (Opened: 46.5)
- FPI Favorite: Texans by 1.1 with a 56% probability to win outright
Sunday Afternoon Slate
Las Vegas Raiders at Los Angeles Chargers (-7)
- Kickoff: 4:05 p.m. ET on CBS
- Moneyline: Raiders (+235); Chargers (-290)
- Total: 44.5 (Opened: 42.5)
- FPI Favorite: Chargers by 5.6 with a 69% probability to win outright
Jacksonville Jaguars at Denver Broncos (-2.5)
- Kickoff: 4:05 p.m. ET on CBS
- Moneyline: Jaguars (+124); Broncos (-148)
- Total: 43.5 (Opened: 44.5)
- FPI Favorite: Jaguars by 0.8 with a 53% probability to win outright
Miami Dolphins at San Francisco 49ers (-12.5)
- Kickoff: 4:25 p.m. ET on Fox
- Line Movement: Opened 49ers -10.5
- Moneyline: Dolphins (+600); 49ers (-900)
- Total: 46.5 (Opened: 46.5)
- FPI Favorite: 49ers by 14.3 with a 91% probability to win outright
Seattle Seahawks (-4.5) at Arizona Cardinals
- Kickoff: 4:25 p.m. ET on Fox
- Line Movement: Opened Seahawks -10
- Moneyline: Seahawks (-225); Cardinals (+185)
- Total: 41.5 (Opened: 44.5)
- FPI Favorite: Cardinals by 1.0 with a 54% probability to win outright
Washington Commanders at Dallas Cowboys (-3.5)
- Kickoff: 4:25 p.m. ET on Fox
- Moneyline: Commanders (+164); Cowboys (-198)
- Total: 50.5 (Opened: 51.5)
- FPI Favorite: Cowboys by 3.8 with a 64% probability to win outright
Sunday Night Football
Indianapolis Colts at Kansas City Chiefs (-6.5)
- Kickoff: 8:20 p.m. ET on NBC
- Moneyline: Colts (+235); Chiefs (-290)
- Total: 48.5 (Opened: 47.5)
- FPI Favorite: Chiefs by 5.7 with a 70% probability to win outright
Monday Night Football
New York Giants at Los Angeles Rams (-7)
- Kickoff: Monday, 8:15 p.m. ET on ESPN, ABC
- Moneyline: Giants (+275); Rams (-345)
- Total: 48.5 (Opened: 47.5)
- FPI Favorite: Rams by 4.5 with a 66% probability to win outright
Note: All odds provided by DraftKings and are subject to change. FPI (Football Power Index) probabilities reflect ESPN’s predictive model.